Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriage

Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriage.

Salmonella enterica serovar Typhi can colonize the gallbladder and persist in an asymptomatic carrier state that is frequently associated with the presence of gallstones. We have shown that salmonellae form bile-mediated biofilms on human gallstones and cholesterol-coated surfaces in vitro. Here, we test the hypothesis that biofilms on cholesterol gallbladder stones facilitate typhoid carriage ...

Prevalence and risk factors for Salmonella spp. colonization in broiler flocks in Shiraz, southern Iran

Salmonella spp. are important food borne pathogens worldwide that frequently infect poultry flocks. This cross-sectional study was conducted to determine the prevalence of Salmonella spp. colonization in broiler flocks in Shiraz (southern Iran) and to find the possible association of infection status with some potential risk factors including vaccination program and use of ant...

Salmonella Extracellular Matrix Components Influence Biofilm Formation and Gallbladder Colonization.

Salmonella enterica serovar Typhi, the causative agent of typhoid fever in humans, forms biofilms encapsulated by an extracellular matrix (ECM). Biofilms facilitate colonization and persistent infection in gallbladders of humans and mouse models of chronic carriage. Individual roles of matrix components have not been completely elucidated in vitro or in vivo To examine individual functions, str...

Histopathological Analysis of Salmonella Chronic Carriage in the Mouse Hepatopancreatobiliary System

Salmonella Typhi asymptomatic chronic carriage represents a challenge for the diagnosis and prevention of typhoid fever in endemic areas. Such carriers are thought to be reservoirs for further spread of the disease. Gallbladder carriage has been demonstrated to be mediated by biofilm formation on gallstones and by intracellular persistence in the gallbladder epithelium of mice. In addition, bot...

TCR Recognition Peptidic Termini Play a Significant Role in